서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2018년 4월 5일 목요일 오후 5시

연사: 김유섭(이화여자대학교)

장소: 서울대학교 25동 411호

TITLE: Multiple modes of positive selection detected by incomplete selective sweeps in African populations of Drosophila melanogaster

ABSTRACT: Positive selection on a new beneficial mutation generates a characteristic pattern of DNA sequence polymorphism when it reaches an intermediate allele frequency. On the genome sequences of African Drosophila melanogaster, we detected such signatures of selection at 37 candidate loci and identified “sweeping haplotypes (SHs)” that are increasing or have increased rapidly in frequency due to hitchhiking. From the geographic distribution of SH frequencies, we could infer whether selective sweeps occurred starting from de novo beneficial mutants under simple constant selective pressure. Single SHs were identified at more than half of loci. However, at many other loci we observed multiple independent SHs, which implies soft selective sweeps either due to a high beneficial mutation rate or parallel evolution across space. Interestingly, SH frequencies are intermediate across multiple populations at about a quarter of the loci despite relatively low migration ates inferred between African populations, which invokes a certain form of frequency-dependent selection such as heterozygote advantage. At one locus, we observed a complex pattern of multiple independent that is compatible with recurrent frequency-dependent positive selection on new variants. In conclusion, the genomic pattern of positive selection are very diverse, with equal contributions of hard and soft sweeps and a surprisingly large proportion of frequency-dependent selection, in D. melanogaster populations.

EDUCATION AND TRAINING

1993 학사 서울대 분자생물학과

1995 석사 서울대 분자생물학과

2002 PhD University of Rochester

2002-2003 Postdoctoral Fellow Cornell University

2003-2005 Postdoctoral Fellow University of Rochester

2006-2010 Assistant Professor Arizona State University

2010-2013 조교수 이화여자대학교

2013- 부교수 이화여자대학교

SELECTED PUBLICATION

Kim, K. & Kim, Y. 2016. Population genetic processes affecting the mode of selective sweeps and effective population size in influenza virus H3N2. BMC Evolutionary Biology, 16:156.

Vy, H.M.T. & Kim, Y. 2015. A composite-likelihood method for detecting incomplete selective sweep from population genomic data. Genetics, 200:633-649.

Moon, S., Kim, T., Lee. K., Kwak, W., Lee, T., Lee, S., Kim, M., Cho, K., (7 more authors), Kim, Y. & Kim, H. 2015. A genome-wide scan for signatures of directional selection in domesticated pigs. BMC Genomics, (2015)16:130.

Kim, Y. & Schneider, K.A. 2013 Evolution of Drug Resistance in Malaria Parasite Populations. Nature Education Knowledge, 4(8):6.

Kim, Y. & Maruki, T. 2011. Hitchhiking Effect of a Beneficial Mutation Spreading in a Subdivided Population. Genetics, 189: 213-226.

Kim, Y. & Gulisija, D. 2010. Signature of directional selection in different models of population expansion during colonization into new selective environments. Genetics , 184:571-585

Innan, H. & Kim, Y. 2008. Detecting local adaptation using the joint sampling of polymorphism in ancestral and derived populations. Genetics , 179:1713-1720.

Kim, Y. 2006. Allele frequency distribution under recurrent selective sweeps. Genetics , 172: 1967-1978.

Xue, Y., Daly, A., Yngvadottir, B., Liu, M., Coop, G., Kim, Y. , Sabeti, P., Chen, Y., Stalker, J., Huckle, E., Burton , J., Leonard, S., Rogers, J. & Tyler-Smith, C. 2006. Spread of an inactive form of caspase-12 in humans is due to recent positive selection. American Journal of Human Genetics , 78:659-70.

Kim, Y. & Orr, H. A. 2005. Adaptation in sexuals vs. asexuals: clonal interference and the Fisher-Muller model. Genetics , 171:1377-1386.

Nielsen, R., Williamson, S., Kim, Y. , Hubisz, M. J., Clark , A. G., and Bustamante, C. D. 2005 . Genomic scans for selective sweeps using SNP data . Genome Res. , 15: 1566-1575.

Jensen, J. D., Kim, Y. , Bauer DuMont, V., Aquadro, C. F. & Bustamante, C. D. 2005. Distinguishing between selective sweeps and demography using DNA polymorphism data. Genetics , 170:1401-1410.

Innan, H. & Kim, Y. 2004. Pattern of polymorphism after strong artificial selection in a domestication event, PNAS , 101:10667-10672.

Kim, Y. & R. Nielsen 2004. Linkage disequilibrium as a signature of selective sweeps, Genetics , 167:1513-1524.

Kim, Y. & Stephan, W. 2002. Detecting a local signature of genetic hitchhiking along a recombining chromosome. Genetics 160: 765-777.

Kim, Y. & Stephan, W. 2000. Joint effects of genetic hitchhiking and background selection on neutral variation. Genetics 155:1415-1427.

서울대학교 생물정보연구소

생물정보학 협동과정 공동주최