서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 열고자 하오니,　많은 참여 바랍니다.

일시: 2015년　4월　30일 목요일 오전　11시

연사:　박 지 연 교수님　(서울대학교 의과대학 의료정보학전공)

장소:　서울대학교　25-1동　103호

TITLE

Integrated analysis of gene mutations and expression signatures on extrathyroidal extension in papillary thyroid cancer

ABSTRACT

Advances in diagnostic technology have increased the likelihood of early detection of thyroid cancer, the most common type of which is papillary thyroid carcinoma (PTC). Although PTCs generally have a good prognosis, but a small proportion of cases has aggressive potential. Extrathyroidal extension (ETE) indicates invasiveness of the primary tumor into the adjacent tissue, and its importance as a prognostic factor overrides tumor size in determining the stage of thyroid cancer. The aim of this study was to determine the molecular basis of ETE using mutation and gene expression profile from The Cancer Genome Atlas (TCGA).

CAREER

2014.06 - present Research Professor in Biomedical Informatics, Seoul National University　College of Medicine

2011.09 - 2014.06　Research Associate in Bioinformatics, Department of Biochemistry and　Molecular Biology, Rutgers New Jersey Medical School, Newark, New Jersey,

2004.05 - 2005.07　Researcher, Division of Genetic Toxicology, Korea Food and Drug　Administration (KFDA), Seoul, Korea

2002.01 - 2004.04　Research Associate, Div. of Biomedical Informatics, Seoul National University　College of Medicine, Seoul, Korea

2000.08 - 2001.07　Researcher, Div. of Molecular Genetics, Samsung Biomedical Research Institute,　Seoul, Korea

1998.09 - 1999.08　Researcher, Division of Immunology, Korea Institute of Radiological and　Medical Sciences, Seoul, Korea

EDUCATION

Ph.D. 2011 University of Medicine and Dentistry of New Jersey, Bioinformatics

M.E. 2003 Sogang University, Information Processing

M.S. 1998 Ewha Womans University, Genetics

B.S., 1995 Ewha Womans University, Biology Education

PUBLICATION (1stauthoronly,includingco-firstauthor)

Li W, You B, Zheng D, Hoque M, Luo W, Ji Z,　Park JY, Gunderson SI, Kalsotra A, Manley JL,Tian B. (2015) Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation. PLoS Genet. In Press

Devany E, Zhang X,　Park JY, Tian B, Kleiman FE. (2013) Positive and negative feedback loops in the p53 and mRNA 3' processing pathways. Proc Natl Acad Sci U S A. 110(9):3351-6.

Matsushima S, Kuroda J, Ago T, Zhai P,　Park JY, Xie LH, Tian B, Sadoshima J. (2013) Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy. Circ Res. 112(4):651-663.

Hoque M*, Ji Z*, Zheng D, Luo W, Li W, You B,　Park JY, Yehia G, Tian B. (2013) Analysis of alternative cleavage and polyadenylation by 3’ region extraction and deep sequencing. Nat Methods. 10(2):133-9.

Bravo C, Kudej RK, Yuan C, Yoon S, Ge H,　Park JY, Tian B, Stanley WC, Vatner SF, Vatner DE, Yan L. (2013) Metabolomic analysis of two different models of delayed preconditioning.　J Mol Cell Cardiol.　55:19-26.

Yan L,　Park JY, Ho D, Lai L, Lorenzo MSD, Dillinger JG, Wang C, Ge H, Yuan Z, Tian B, Stanley WC, Auwerx, J, Vatner DE, Vatner SF. (2012) Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity. Aging Cell. 11(5):1110-20

Yin JW, Liang Y,　Park JY, Liu Z, Jiang B, Fu Y, Huang Y, Liu Y, Yan J, Li D, Tian B, Wang G. (2012) The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 26(19):2192-205

Xie LH, Shanmugam M,　Park JY, Zhao Z, Tian B, Periasamy M and Babu GJ. (2012) Ablation of sarcolipin results in atrial remodeling. Am J Physiol Cell Physiol. 302(12): C1762-71

Zhao X,　Park JY, Ho D, Gao S, Yan L, Ge H, Ilsmaa S, Lin L, Tian B, Vatner DE, Graham R, Vatner SF. (2012) Cardiomyocyte overexpression of the　α1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning. Am J Physiol Heart Circ Physiol. 302(8):H1614-24

Oka SI, Zhai P, Alcendor R,　Park JY, Tian B, Sadoshima J. (2012) Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart. Cell Cycle. 11(5):856-64

Oka S, Alcendor R, Zhai P,　Park JY, Shao D, Cho J, Yamamoto T, Tian B, Sadoshima J. (2011) PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab. 14(5):598-611.

Qiu H, Lizano P, Laure L, Sui X, Rashed E,　Park JY, Hong C, Gao S, Holle E, Morin D, Dhar SK, Wagner T, Berdeaux A, Tian B, Vatner SF, Depre C. (2011) H11 Kinase/Hsp22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure upon cardiac overload. Circulation 124(4): 406-415

Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. (2011) Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS One 6(7):e22391

Usui S, Maejima Y, Pain J, Hong C, Cho J,　Park JY, Zablocki D, Tian B, Glass DJ, Sadoshima J. (2011) Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res. 109(2):161-171

Zhao Q, Beck AJ, Vitale JM, Schneider JS, Gao S, Chang C, Elson G, Leibovich SJ,　Park JY, Tian B, Nam HS, Fraidenraich D. (2011) Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes. Dev Biol. 349(1):53-64.

Depre C,　Park JY, Shen YT, Zhao X, Qiu H, Yan L, Tian B, Vatner SF, Vatner DE. (2010) Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window. Am J Physiol Heart Circ Physiol. 299(3):H752-62.

Shen YT, Depre C, Yan L,　Park JY, Tian B, Jain K, Chen L, Zhang Y, Kudej RK, Zhao X, Sadoshima J, Vatner DE, Vatner SF. (2008) Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation 118(19):1961-1969

Lee JY,　Park JY, Tian B. (2008) Identification of mRNA polyadenylation sites in genomes using cDNA sequences, expressed sequence tags, and Trace. Methods Mol Biol. 419:23-37

Dass B, Tardif S,　Park JY, Tian B, Weitlauf HM, Hess RA, Carnes K, Griswold MD, Small CL, Macdonald CC. (2007) Loss of polyadenylation protein　τCstF-64 causes spermatogenic defects and male infertility. Proc Natl Acad Sci U S A. 104(51):20374-20379

Lee JY, Yeh I,　Park JY, Tian B. (2007) PolyA_DB 2: mRNA polyadenylation sites in vertebrates genes. Nucleic Acids Res. 35(Database issue):D165-D168

Yoon CY, Park M, Kim BH,　Park JY