서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2017년 12월 07일 목요일 오전 11시

연사: 이호선 (국립과학수사연구소)

장소: 서울대학교 25동 411호

Title : Interaction between age at menarche and genetic polymorphisms on traits of metabolic syndrome

Abstract : Early menarche has been associated with increased risk of metabolic syndrome (MetS). Although MetS has a significant genetic component, limited evidence, to date, supports a common genetic background underlying an association of age of menarche and MetS. Therefore, we evaluated previous GWAS-identified genetic variants for interactions between specific SNPs and age at menarche. At first, we identified the risk of MetS incidence was significantly increased only at 12 ≤ years of age at menarche. Women with early menarche (≤12 years) also had significantly higher levels of triglycerides and waist circumference. For gene-environment interaction, we identified 2 SNPs located on chromosome 2 (intergenic to the SCG2) were associated with triglycerides including the genetic interaction with age at menarche. These two SNPs were not associated with triglycerides in a main effect only model. These findings may help us understand the role of age at menarche on development of MetS, and gene-environment interactions that confer MetS susceptibility.

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서울대학교 생물정보학 협동과정 주최