서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2017년 9월 14일 목요일 오전 11시

연사: 김병찬(한국생명공학연구원 대사제어연구센터)

장소: 서울대학교 25동 411호

TITLE: Clinical Revolution by Anaerobic Human Gut Microbiota

ABSTRACT: In the past decade, the study of the human microbiome has come to the forefront of biological research. The human symbiotic microbiota and its metabolites influence not only gastrointestinal and nutritional diseases such as Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel disease, obesity and diabetes but also a host of other human diseases including cancer, arteriosclerosis, Alzheimer’s, and Parkinson’s. More generally, the microbiota has a significant effect on birth, growth, development, aging, lifespan, and even on the human brain and behaviour. However, most research into the human microbiome thus far has focused exclusively on microbial diversity and metagenomic analysis through next-generation sequencing (pyrosequencing) techniques. In the next phase, research should focus on the isolation of foundation species and their clinical applications for preventing and curing these microbiota-related human diseases. Aerobic and facultative anaerobic microbes such as E. coli, Bacillus spp. and Lactobacillus spp. are easy to isolate and cultivate; pure cultures of these species are readily available and they, along with their commercial applications, have been studied for a century already. However, recent research has shown that obligate anaerobes in the human gut have a more profound impact on human diseases. Several global drug companies have created cocktails of human gut anaerobes for use in faecal microbiota transplantation (FMT); some of these cocktails are currently undergoing clinical trials as treatments for human diseases, and are almost ready for commercial release.

In this presentation, I provide several examples of how these gut anaerobes are important for human health and introduce techniques for the anaerobic culturomics of human gut microbiota. Three years ago, we began isolating novel human anaerobic microorganisms from faecal samples. Now we have more than 3000 strains of over 300 different bacterial species, including more than 100 potentially novel species. Some of these are methanogens isolated for the first time in Korea, and some are already being studied in vivo using mouse models to explore their physiological benefits to their hosts.

EDUCATION AND TRAINING

1991.03. ~ 1995.02. 연세대학교 생명공학과 공학사

1995.03. ~ 1997.02. 연세대학교 생명공학과 공학석사

1997.03. ~ 2001.02. 연세대학교 생명공학과 공학박사

1997.07. ~ 1997.09. & 1998.02.~ 1998.04. 독일 Technical University of Hamburg-Harburg 방문연구원

2001.03. ~ 2003.02. 연세대학교 생물산업소재연구센터 전임연구원

2003.03. ~ 2007.08. 매사추세츠 주립대학 미생물학과 박사후 연구원

2007.09. ~ 2009.07. 매사추세츠 주립대학 미생물학과 연구교수

2009.08. ~ 현재 한국생명공학연구원(KRIBB) 선임연구원

2011.09. ~ 현재 과학기술연합대학원대학교(UST) 생물공정공학전공 부교수

2012.09. ~ 현재 충남대학교 생물환경화학과 겸임교수

2016.01. ~ 현재 한국미생물생명공학회 주무간사

SELECTED PUBLICATION

- Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa. 2016. PNAS. 113:E762-E771. (2저자)

- Agathobaculum butyriciproducens gen. nov. sp. nov., a strict anaerobic, butyrate-producing gut bacterium isolated from human faeces and reclassification of Eubacterium desmolans as Agathobaculum desmolans comb. nov. IJSEM 2016. 66:3656-3661 (우리나라 최초 장내 butyrate 생산 신속 미생물 보고, 교신저자)

- Dermabacter vaginalis sp. nov., isolated from human vaginal fluid. IJSEM 2016. 66:1881-1886 (우리나라 최초 한국인 여성 질내 신종 미생물 보고, 교신저자)

- Faecalibaculum rodentium gen. nov., sp. nov., isolated from the faeces of a laboratory mouse. 2015. Antonie van Leeuwenhoek. 108:1309-1318. (우리나라 최초 마우스 장내 신속 미생물 보고 – 노화 관련, 교신저자)

- Whole genome sequencing of “Faecalibaculum rodentium” ALO17, isolated from C57BL/6J laboratory mouse feces. 2016. Gut pathogen. 8:3 (마우스 노화 관련 미생물 ALO17의 게놈 분석 논문, 교신저자)

- Whole-genome sequence of Erysipelothrix larvae LV19T (=KCTC 33523T), a useful strain for arsenic detoxification, from the larval gut of the rhinoceros beetle, Trypoxylus dichotomus. 2016. Journal of Biotechnology. 223:40-41. (우리나라 최초 비소 분해 장내 미생물 신종 게놈 분석, 교신저자)

- Methanobrevibacter boviskoreani sp. nov., isolated from the rumen of Korean native cattle 2013. IJSEM. 63:4196-4201 (우리나라 최초 메탄균 신종 보고)

- Tunable metallic-like conductivity in microbial nanowire networks. 2011. Nature nanotechnology. 6:573-579. (공동저자)

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