서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2016년 11월 16일 수요일 오전 11시

연사: 김영준 (연세대학교)

장소: 서울대학교 25동 411호

Title

Cell type-specific regulation by intragenic CpG islands

Abstract

CpG islands have long been known for their association with enhancers, silencers, and promoters, and for their epigenetic signatures. They are maintained in embryonic stem (ES) cells in a poised but inactive state, by the formation of bivalent chromatin, containing both active and repressive marks. CpG islands also occur within coding sequences, where their functional role has remained obscure. Intragenic CGIs are largely absent from housekeeping genes, but they are found in all genes associated with organ development and cell lineage control. We have investigated the epigenetic status of intragenic CGIs and found that they too reside in bivalent chromatin in ES cells, with important differences from enhancers, silencers and promoters. Intragenic CGIs bind cell type-specific transcription factors, and they resolve upon cell differentiation by hypermethylation, spreading to promoters, and resulting in active transcription. Intragenic CGIs thus play a key role in the cell type-specific regulation of transcription.

Educational Experience

Professional Experience

Selected Publications

　Sun-Min Lee, Jeongsil Kim-Ha, Won-Young Choi, Jungwoo Lee, Dawon Kim, Jinyoung Lee, Eunji Choi & Young-Joon Kim. (2016) Interplay of genetic and epigenetic alterations in hepatocellular carcinoma. Epigenomics. 8(7):993-1005

Wook-Bin Lee, Ji-Seon Kang, Won Young Choi, Quanri Zhang, Chul Han Kim, Un Yung Choi, Jeongsil Kim-Ha & Young-Joon Kim. (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. NAT COMMUN. 7(11322):1-14

Chan Kyu Sim, Yeon Sook Cho, Byung Soo Kim, In-Jeoung Baek, Young-Joon Kim, Myeong Sup Lee. (2016) 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. CANCER IMMUNOL IMMUN. 1-13

Ji Eun Oh1, Myeong Sup Lee, Young-Joon Kim, Heung Kyu Lee. (2016) OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. SCIENTIFIC REPORTS. 6(19089)

Sun-Min Lee, Won-Young Choi, Jungwoo Lee and Young-Joon Kim. (2015) The regulatory mechanisms of intragenic DNA methylation. Epigenomics. 7(4):527-531

Yuichiro Hatano, Katsunori Semi, Kyoichi Hashimoto, Myeong Sup Lee, Akihiro Hirata, Hiroyuki Tomita, Toshiya Kuno, Manabu Takamatsu, Koji Aoki, Makoto M Taketo, Young-Joon Kim, Akira Hara and Yasuhiro Yamada. (2015) Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis. 36(7):719-729

Un Yung Choi, Won Young Choi, Ji Yeon Hur and Young-Joon Kim. (2015) Polyubiquitin chain-dependent protein degradation in TRIM30 cytoplasmic bodies. EXP MOL MED. 47(e159):1-7

Un Yung Choi, Ji-Seon Kang, Yune Sahng Hwang and Young-Joon Kim. (2015) Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases. EXP MOL MED. 47(e144):1-6

Yun-Mi Kim, Won-Young Choi, Chang-Mok Oh, Gyoon-Hee Han and Young-Joon Kim. (2014) Secondary structure of Irf7 5’-UTR analyzed using SHAPE (selective 2’-hydroxyl acylation analyzed by primer extension). BMB REP. 47(10):558-562

Sun-Min Lee, Young-gun Lee, Jae-Bum Bae, Jung Kyoon Choi, Chiharu Tayama, Kenichiro Hata, Yungdae Yun, Je-Kyung Seong, and Young-Joon Kim. (2014) HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators. PNAS. 111(26):9555-9560

Un Yung Choi, Ji Yeon Hur, Myeong Sup Lee, Quanri Zhang, Won Young Choi, Lark Kyun Kim, Wook-Bin Lee, Goo Taeg Oh, Young-Joon Kim. (2014) Tripartite Motif-Containing Protein 30 Modulates TCRActivated Proliferation and Effector Functions in CD4+ T Cells. PLOSONE. 9(Issue4):1-11

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