제목	2016년 05월 25일(수) 생물정보학세미나
작성자	관리자	작성일	2016-05-17
서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.　 일시: 2016년 5월 25일 수요일 오전 11시,　 연사: 황대희 (DGIST) 장소: 서울대학교 25동 411호　 [Title] An integrative proteogenomics approach in gastric cancer [Abstract] Agreement between genomic and proteomic molecular signatures can be used to identify core disease-related signatures. Recently, proteogenomics analyzing proteomic and genomic data for the same biological samples has emerged to identify these core molecular signatures related to diseases. In this study, we performed mRNA- and exome-sequencing and also global protein and phosphorylation profiling of the tissues collected from 50 gastric cancer tissues and matched normal tissues. By integrating proteomic and genomic datasets, we analyzed agreements between two datasets, identified subgroups of disease samples based on two datasets, and selected cellular pathways represented by both proteomic and genomic datasets as core pathways of gastric cancer. Our results demonstrate the power of analyzing collectively multiple global datasets in selecting the core disease-related pathways. Currently, the clinical implications of the identified core gastric cancer pathways are being verified using independent samples by multiple reaction monitoring technics. [Education] 2003-2005 　 　　Institute for Systems Biology, Seattle, WA 　 　 　 　Postdoctoral Fellow 　 　 　 　 　Data Integration and Network Reverse Engineering (Dr. Leroy Hood) 1999-2003 　 　 　Massachusetts Institute of Technology, Cambridge, MA 　　 　 　 　 　 　Ph.D., Chemical Engineering 　 　 　 　 　 　 A Statistical Framework for the extraction of Structured Knowledge from　 　 　 　 　Biological/Biotechnological Systems (Dr. George & Gregory Stephanopoulos) [Professional Experiences] 2013.10- 　 　 　Daegu Gyeongbuk Institute of Science & Technology, Daegu, Korea 　 　 　 　Department of New Biology, Professor 2010.9-2011.8 System Bio-dynamics National Core Research Center, Pohang, Korea 　 　 　 　School of Interdisciplinary Bioscience and Bioengineering, Director 2006.8-2013.9 Pohang University of Science and Technology, Pohang, Korea 　 　 　 　School of Interdisciplinary Bioscience and Bioengineering & 　 　 　 　Chemical Engineering, Assistant & Associate Professor 2006.1-2006.8 Institute for Systems Biology, Seattle, WA 　 　 　 　Senior Scientist 　 　 　 　Data Integration and Network Reverse Engineering in Disease Models [Recent Publications] S.H. Hwang, S. Jung, S. Lee, S. Choi, S. Yoo, J. Park, D.Hwang, S.C.Shim, L.Sabbagh, S.Park,C.Cho, B.Kim,L.Leng, R.R.Montgomery, R.Bucala,Y.Chung,and W.Kim.　 Leukocyte-Specific Protein 1 Regulates TCell Migration and Inflammatory Arthritis. Proceedings of the National Academy of Sciences, 112, 47, E6535-E6543 (2015). J. Park†, J. Park†, D. Mun†, J. Bae†, J.H. Jung, S. Back, H. Lee, H. Kim, H. Jung, H.K. Kim, H. Lee, K.P. Kim*, D.Hwang*, S.Lee*.　 Integrated analysis of global proteome, phosphoproteome, and glycoproteome enables complementary interpretation of disease-related protein networks. Scientific reports (accepted for publication) (2015). Y. Park, C. Cho, D.Hwang, S.Yoo, and W.Kim.　 Identification of novel urinary biomarkers for Assessing Disease Activity and Prognosis of Rheumatoid Arthritis. Experimental & Molecular Medicine (accepted for publication) (2015). Y. Kim , H.J. Nam , J. Lee , D.Y. Park , C. Kim , Y.S. Yu , D. Kim , S.W. Park , J. Bhin , D.Hwang, H.Lee, G.Y.Ko, and S.H.Baek.　 Methylation-dependent Regulation of HIF-1α Stability Restricts Retinal and Tumour Angiogenesis. Nature Communications (accepted for publication) (2015). Han EJ, Yoo SA, Kim GM, HwangD, ChoCS, YouS, and KimWU. GREM1 is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness. The Journal of Rheumatology (accepted for publication) (2015). Park MC, Jeong H, Son SH, Kim Y, Han D, Goughnour PC, Kang T, Kwon NH, Moon HE, Paek SH, HwangD, SeolHJ, NamDH, KimS. Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function. Cancer Research, 76, 5, 1044-54 (2016). S.K Yoon. Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation. Oncotarget (accepted for publication) (2016). H.R. Woo*, H.J. Koo*, J. Kim*, H. Jeong*, J.O. Yang, I.H. Lee, J.H. Jun, S.H. Choi, S.J. Park, B. Kang, Y.W. Kim, B. Phee, J.H. Kim, C. Seo, C. Park, S.C. Kim, S. Park, B. Lee, S. Lee, D.Hwang**, H.G.Nam**, and P.O.Lim**. Programming of plant leaf senescence with temporal and inter-organellar coordination of transcriptome in Arabidopsis. Plant Physiology (accepted for publication) (2016). D.H. Jo*, J. Bae*, S. Chae*, J.H. Kim, J. Han, D.Hwang#, S.Lee#, and J.H.Kim#. Quantitative proteomics reveals β2integrin-mediated cytoskeletal rearrangement in VEGF-induced retinal vascular hyperpermeability. Molecular & Cellular Proteomics (accepted for publication) (2016). H.Y. Yoo, M. Iordachescu, J. Huang, E. Hennebert, S. Kim, S. Rho, M. Foo, P. Flammang, H. Zeng, D.Hwang, J.H.Waite, D.S.Hwang. Where stiff meets soft: sugary interfaces mitigate contact damage.　 Nature Communications (accepted for publication). S. Devkotaa, H. Jeong, Y. Kim, M. Ali, J. Roh, D. Hwang*, and H. Lee*. Functional characterization of EI24-induced autophagy in the degradation of RING domain E3 ligases. Autophagy (accepted for publication).　 서울대학교 생물정보연구소 생물정보학 협동과정 공동주최