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ÀÛ¼ºÀÚ | °ü¸®ÀÚ | ÀÛ¼ºÀÏ | 2015-10-20 |
¼¿ï´ëÇб³ »ý¹°Á¤º¸ÇÐ Çùµ¿°úÁ¤ ÁÖÃַΠƯº° ¼¼¹Ì³ª¸¦ ¾Æ·¡¿Í °°ÀÌ ¿°íÀÚ ÇÏ¿À´Ï, ¸¹Àº Âü¿© ¹Ù¶ø´Ï´Ù. ¡¡ ÀϽÃ: 2015³â 10¿ù 28ÀÏ ¼ö¿äÀÏ ¿ÀÀü 11½Ã ¿¬»ç: ¼ºÁ¦°æ (¼¿ï´ëÇб³ ¼öÀÇ°ú´ëÇÐ) Àå¼Ò: ¼¿ï´ëÇб³ 25µ¿ 411È£ ¡¡ Title: Human Gene Function Catalogue from Mouse Phenotyping Data Abstract Mouse models are crucial for the functional annotation of human genome. Gene modification techniques including gene targeting and gene trap in mouse have provided powerful tools in the form of genetically engineered mice (GEM) for understanding the molecular pathogenesis of human diseases. Several international consortium and programs are under way to deliver mutations in every gene in mouse genome. The information from studying these GEM can be shared through international collaboration. However, there are many limitations in utility because not all human genes are knocked out in mouse and they are not yet phenotypically characterized by standardized ways which is required for sharing and evaluating data from GEM. The recent improvement in mouse genetics has now moved the bottleneck in mouse functional genomics from the production of GEM to the systematic mouse phenotype analysis of GEM. Enhanced, reproducible and comprehensive mouse phenotype analysis has thus emerged as a prerequisite for effectively engaging the phenotyping bottleneck. Here, current information on systematic mouse phenotype analysis and an issue-oriented perspective will be provided. ¡¡ Çз 1986-1990 ¼¿ï´ëÇб³ ¼öÀÇ°ú´ëÇÐ Çлç 1990-1992 ¼¿ï´ëÇб³ ´ëÇпø ¼®»ç 1992-1995 ¼¿ï´ëÇб³ ´ëÇпø ¹Ú»ç ¡¡ °æ·Â 1995-1996 ÀϺ» ³ª°í¾ß´ëÇб³ °´¿ø¿¬±¸¿ø 1996-2002 ¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ½ÇÇ赿¹°ºÎ Á¶±³¼ö 1998-1999 KAIST ºÐÀÚ»ý¸í°úÇкΠ°âÀÓ±³¼ö 2002-2015 ÇöÀç ¼¿ï´ëÇб³ ¼öÀÇ°ú´ëÇÐ Á¶±³¼ö, ºÎ±³¼ö, Á¤±³¼ö 2005-2015 ÇöÀç ¼¿ï´ëÇб³ »ý¹°Á¤º¸ÇÐ Çùµ¿°úÁ¤ °âÀÓ±³¼ö 2008-2015 ÇöÀç ¼¿ï´ëÇб³ Á¾¾ç»ý¹°ÇÐ Çùµ¿°úÁ¤ °âÀÓ±³¼ö ¡¡ ¡¡ ¡¡ ¡¡ ¡¡ »ý¹°Á¤º¸ÇÐ Çùµ¿°úÁ¤ ÁÖÃÖ |
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