서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2015년 10월 14일 수요일 오전 11시

연사: 안태진 (삼성전자)

장소: 서울대학교 25동 411호

Title: Personalized identification of altered pathways in cancer using accumulated normal tissue data

Abstract

Identifying altered pathway in an individual is important in understanding disease mechanism and future application of custom tailored therapeutic decision. Existing pathway analysis techniques are mainly focused on discovering altered pathways between two phenotype groups. Thus, we suggest a new approach for personalized identification of altered pathway, especially making use of accumulated normal data for cases when a patient's matched normal data is unavailable. Philosophy of our method is to measure how much an individual sample's pathway is deviated when it is compared to many accumulated normal samples (the 'reference').

We suggest the most feasible ways to summarize an individual pathway aberrance score (iPAS) for two major challenges of biology, diagnosis and prognosis. Our unsupervised approach clearly captures discriminate histophethological differentiation status of a cancer, sensitively features known ground truth of cancer biology and improves validation rate of discovered survival pathways (n=442 for discovery set, n=61 for independent validation) than conventional analysis scheme. In addition to increased performance, our method is biologically easy to interpret. Our method approach is also useful to identify cancer. We discovered and validated a pathway which is good classifier of cancer in lung adenocarcinoma data set (n=240 for discovery set, n=83 for independent validation). As a result, We propose mahalanobis distance as iPAS for the diagnoss, averaged z-value for prognosis or other types of phenotype association study.

Work Experience

2001.8 ~ present Samsung Advanced Institute of Technology, Giheung, Korea

2001.3 ~ 2001.7 3rd Millenium, Boston, USA

1999.3 ~ 2001.2 BRIC, Postech, Pohang, Korea

Education

Ph.D. Bioinformatics program (part time), Seoul National University, South Korean (2008-2014), Majored in Biostatistics and Bioinformatics

M.Sc. Division of Molecular and Life Sciences (1999-2001), POSTECH (Pohang University of Science and Technology), South Korea, Majored in Bioinformatics

B.Sc. Department of Bioscience and Food engineering, Handong University, South Korea (1995-1999), Majored in Bioscience, Computer Science as minor

Awards and Scholarships

Bronze award, Samsung global best paper, Nov, 2009

Customer satisfaction prize from Samsung Advanced Institute of Technology, Sep, 2004

The highest honor degree at graduation (B.S.) – 1st in the department, Feb, 1999

Fellowship from HandongUniversity(6times),1995-1999

Recent Publications

1. TaeJin Ahn, Taesung Park: Pathway-driven discovery of rare mutational impact on cancer. Biomed Research International, Article ID 171892 (2014)

2. B Kim, S Wang, JM Lee, Y Jeong, TaeJin Ahn, D-S Son, HW Park, H-s Yoo, Y-J Song, E Lee, YM Oh, SB Lee, J Choi, JC Murray, Y Zhou, PH Song, K-A Kim and LM Weiner Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy, Oncogene, 2014

3. Yeon Hee Park · Hyun-Tae Shin · Hae Hyun Jung · Yoon-La Choi · TaeJin Ahn · Kyunghee Park · Aeri Lee · In-Gu Do · Ji-Yeon Kim · Jin Seok Ahn · Woong-Yang Park · Young-Hyuck Im. Role of HER2 mutations in refractory metastatic breast cancers: targeted sequencing results in patients with refractory breast cancer,Oncotarget 09/2015; DOI:10.18632/oncotarget.5184

4. Ji Yun Lee · Sun Young Kim · Charny Park · Nayoung K D Kim · Jiryeon Jang · Kyunghee Park · Jun Ho Yi · Mineui Hong · Taejin Ahn · Oliver Rath ·· Se Hoon Park · Yong Ick Ji · Dukwhan Kim · Joon Oh Park · Young Suk Park · Won Ki Kang · Kyoung-Mee Kim · Woong-Yang Park · Ho Yeong Lim · Jeeyun Lee, Patient-derived cell models as preclinical tools for genome-directed targeted therapy, Oncotarget 07/2015; 6(28). DOI:10.18632/oncotarget.4627 ·

5. Kyunghee Park · Moon Ki Choi · Hae Hyun Jung · In-Gu Do · Kwang Hee Lee · TaeJin Ahn · Won Ho Kil · Seok Won Kim · Jeong Eon Lee · Seok Jin Nam · Duk-Hwan Kim · Jin Seok Ahn · Young-Hyuck Im · Yeon Hee Park, Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay, Oncotarget 05/2015; 6(27). DOI:10.18632/oncotarget.4119 ·

Patents [main inventor]

“Method for diagnosing cancer micro-metastasis using genetic markers,” Korea Patent Application, 2006

“Method for identifying existence of targeted DNA sequence in mixed DNA sample,” U.S. Patent Application, 2005, Korea Patent, 2005

“Selecting common or specific DNA sequence for detecting probe,” U.S. Patent Application, 2004, Korea Patent, 2006

“Method for encoding and storing DNA sequence data of an organism when its genome is identified,” U.S. Patent Application, 2003, Korea Patent, 2005

“Method and apparatus of ciphering DNA sequences,” U.S. Patent Application, 2003, Korea Patent, 2004

"Method, medium, and system for encrypting and/or decrypting information of microarray," U.S. Patent Application, 2009

"Method and apparatus for integrated personal genome management," U.S Patent Application, 2010

"Method and apparatus for selecting pharmacogenomic markers", U.S Patent Application, 2010

"Method and apparatus for searching nucleic acid sequence", U.S Patent Application, 2011

" Method and apparatus for recovering gene sequence using probe map", U.S Patent Application, 2012

"Method of identifying target biomolecule by using probe-binding frequency", U.S Patent Application, 2012 -

" Method and apparatus for compressing genetic data", U.S Patent Application, 2013

" Method and apparatus for compressing and decompressing genetic information obtained by using next generation sequencing (ngs)", ", U.S Patent Application, 2013

“Intrusion code detection with personal immunity,” U.S. Patent Application, 2007, Korea Patent Application, 2007

“Method for updating immune system for mobile handsets,” U.S. Patent Application, 2007, Korea Patent Application, 2007

“Method for early detection of malwares epidemics via network monitoring,” U.S. Patent Application, 2007, Korea Patent Application, 2007

“Mobile immune system,” Patent U.S. Patent Application, 2007, Korea Patent Application, 2007

“Method for detecting malwares by immune system,” U.S. Patent Application, 2007, Korea Patent Application, 2007

“Method and apparatus for intrusion code detection,” U.S. Patent Application, 2006, Korea Patent Application, 2006

서울대학교 생물정보연구소

생물정보학 협동과정 공동주최