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Title: The architecture and regeneration of skin tissue in spiny mice


Abstract

In most mammals, wound-induced tissue regeneration is incomplete and results in fibrotic scarring. How adult stem cells lose their regenerative potential and the trade-off of incomplete regeneration remain unknown. Interestingly, the African spiny mouse (Acomys spp.) is a unique mammalian species that can autotomize its skin to escape from predators and completely regenerate it as with salamanders. The naturally-developed robust tissue recovery of A. cahirinus serves as a powerful model system to study complete tissue regeneration in mammals. I will briefly introduce some recent progresses of our study on tissue regeneration in A. cahirinus.