서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다.

세미나는 대면 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래 일시와 장소를 참고하여 주시길 바랍니다.

일시: 2024년 4월 2일 화요일 오전 11시

연사: 황병진 교수님 (연세대학교)

장소: 500동 L304호

(500동건물에서 503동 건물 방향 엘리베이터 이용)

Title: Scalable, single cell multi-omics

Abstract

With increasing availability of the single-cell sequencing platforms, researchers are making exciting discoveries to transform biomedical research. However, current technologies can assess only handful of cells (1,000-10,000) due to limitation in the microfluidic encapsulation inefficiency. To date, most of the research has been focused on measuring RNA expression, often missing important phenotyping information. Biologists heavily relied on Flow cytometry or Mass cytometry to phenotype cells with limited number of markers. Here, I will introduce how the combinatorial indexing-based methods can be leveraged to achieve ultra-high throughput profiling of single-cell level multimodal expression patterns to topple technical barriers and discuss further how we envision single-cell perturbation study in genome-wide scale for the first time. As the sequencing cost continues to decrease, ultra high-throughput technology will democratize population-scale single cell studies and provide better insights into cellular interactions and heterogeneity in complex biological processes to delve deeper into human disease pathogenesis.