서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다.

세미나는 온라인 및 오프라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래의 링크 혹은 장소로 참석 부탁드리겠습니다.

*줌으로 참석하기 위해서는 "참석자로 회의 참가" --> 이름, 성, 이메일 주소, 이메일 주소 확인을 입력하시고 등록하시면 회의 참석이 가능합니다.

일시: 2023년 6월 8일 목요일 오전 11시

연사: 성연주 교수님 (Washington University)

(온라인) Zoom link: http://snu-ac-kr.zoom.us/s/92890734315

(오프라인) 장소: 서울대학교 300동 611호

Molecular Profiling to Enable Precision Medicine In Neurodegenerative Disease

Alzheimer's disease(AD) is the most common form of demetia and neurodegeneration without any effective treatment. Functional mechanisms and downstream effects of AD associated genes and variants have not yet been fully characterized. Our group has pioneered the generation and use of multi-omic data (genomics, epigenomics, transcriptomics, proteomics, metabolomics, and lipidomics). We recently generated proteomics data (7028 aptamers, SomaScan 7K) in cerebrospinal fluid (CSF) from over 3000 individuals. In my talk, I will be presenting three projects based on this data. In thefirst project, we performed genome-wide association study (GWAS) of sTREM2 and subsequent follow-up functional validation with human peripheral blood mononuclear cell (PBMC)-derived macrophages to identify genetic modifiers that can serve as novel therapeutic targets for AD. In the second project, we performed protein quantitative trait loci (pQTL) and subsequent integration with proteome-wide association study (PWAS),Mendelian randomization (MR), and co-localization to prioritize novel candidate genesinvolved in AD. In the third project, we identified sex and aging signatures in human CSF proteomics and distinct clusters that are linked to human aging diseases. These three projects support the development of proteomics data in neurologically-relevant tissues, which ultimately help creating individualized disease risk evaluation and treatment.