서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다.

세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래의 링크로 참여 부탁드리겠습니다.

*줌으로 참석하기 위해서는 "참석자로 회의 참가" --> 이름, 성, 이메일 주소, 이메일 주소 확인을 입력하시고 등록하시면 회의 참석이 가능합니다.

일시: 2023년 3월 30일 목요일 오전 11시

연사: 조남혁 교수님 (서울대학교)

Zoom link: http://snu-ac-kr.zoom.us/s/94062169492

Title: Evolution and Pathogenesis of Human Coronaviruses

Nam-Hyuk Cho

Department of Microbiology and Immunology,

Seoul National University College of Medicine

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and often results in fatal pneumonia. Despite the worldwide effect of the COVID-19 pandemic, the underlying mechanisms of the fatal viral pneumonia remain elusive. In order to characterize the inflammatory features associated with the viral pneumonia in COVID-19 patients, clinical specimens, including bronchoalveolar lavage fluids (BALFs), sputa, lung biopsies, and bloods collected from confirmed cases of COVID-19 patients with varying degrees of disease severity were extensively analysed. In addition, we also examined and compared the viral dynamics and systemic immune responses observed in patients with COVID-19 and Middle Ease Respiratory Syndrome (MERS). Kinetic profiling of multiple inflammatory mediators showed complex dysregulation of innate and adaptive immune responses, which also associated with differential pulmonary inflammation in COVID-19 and MERS. In this presentation, I will also present and discuss evolutionary pathways of the emerging coronavirus infections, COVID-19 and MERS, which often resulting in fatal pneumonia.