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¿¬»ç: ÀÌÁ¤¼® ±³¼ö´Ô (KAIST)

Zoom link: http://snu-ac-kr.zoom.us/s/97426078205


Title: Single-Cell Transcriptome Analysis of Perturbed Immune System in Inflammatory Diseases

Abstract

To understand immunologic mechanisms of pathologic hyper-inflammation and their pharmacologic intervention in COVID-19 and other inflammatory disorders, we performed single-cell RNA sequencing of blood and tissue immune cells from patients and animal models. The cohorts were designed to analyze the effects of virus, vaccine, corticosteroid, or other immunosuppressive agents with longitudinal design. Here, we found unique transcriptomic and epigenetic characteristics of responsive and refractory features giving ideas for future strategies of personalized immune-modulation in the inflammatory diseases.