서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다.

세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래의 링크로 참여 부탁드리겠습니다.

*줌으로 참석하기 위해서는 "참석자로 회의 참가" --> 이름, 성, 이메일 주소, 이메일 주소 확인을 입력하시고 등록하시면 회의 참석이 가능합니다.

일시: 2022년 10월 6일 목요일 오전 11시

연사: 김규태 교수님 (아주대학교)

Heterogenous cellular behaviors are tightly regulated in the environment in which they interact with each other via intercellular communication. Charting the cell-by-cell functional topologies and modelling disharmonized cell-to-cell signaling transduction is the key to understand disease etiology and prevention. One of the major environmental forces is the immune system. In this talk, I will show evolutionary mechanisms of escape from immunotherapy in pursuing to identify approaches to empower the innate arm of the immune system in multiple refractory disease cases including cancer. Mutational signatures associated with the disease were identified based on genetic profiling, and clonal kinetics uncovered the patterns related to immune response (predator-prey growth kinetics). To more explicitly probe the co-evolution of the malignancy and the immune system, and to dissect heterogenous cellular behaviors in admixture cell population, single-cell sequencing was adopted. Detection of rare cell populations including exhausted T cell subtypes (e.g. stem-like and terminally differentiated) leveraged to understand the immune interaction in its most active context, providing an actional understanding of response to immune checkpoint blockade, and better therapeutic design.