세미나/행사

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제목 2022년 5월 12일 생물정보학 세미나
작성자 관리자 작성일 2022-05-10

서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다.

세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래의 링크로 참여 부탁드리겠습니다.


일시: 2022년 5월 12일 목요일 오전 11시

연사: 방두희 연사님 (연세대학교)


Title:　Cell-free tumor dna as a cancer surveillance strategy
Recent studies on ctDNA have shown that the "liquid biopsy" is very attractive for monitoring of minimal residual cancers that cannot be sampled without invasive means. However, mutations from the tumor comprise only a small fraction of plasma DNA, and thus require very high-depth sequencing for reliable identification of minimal residual disease. In the presentation, we will discuss what are the optimal methods for the detection of MRD. Recently, we have actively explored mutation-based tissue informed methods; with colon cancer patient cohorts, we were able to predict relapse with high PPV. Furthermore, ctDNA based MRD analysis can be done without tissue and/or methylation-based means. We will also discuss pros/cons of strategies implementing individualized panels, pre-designed targeted panels, or genome-wide analysis.