제목	2021년 10월 14일 생물정보학 세미나
작성자	관리자	작성일	2021-10-11
서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다. 세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래의 링크로 참여 부탁드리겠습니다. 일시: 2021년 10월 14일 목요일 오전 11시 연사: 이대엽 연사님 (KAIST) Zoom link:　https://snu-ac-kr.zoom.us/j/86169785192 Title:　The chromatin remodeler Ino80 mediates RNAPII pausing site determination Abstract The protein complexes that control RNA polymerase II (RNAPII) elongation rate and processivity are poorly understood. Moreover, it is unclear how chromatin remodelers affect transcription elongation through communicating with RNAPII. To address these questions, we utilized the simple yeast genetics, high-throughput genome analysis, and bioinformatic technique to analyze RNAPII transcription elongation in vivo. Especially, we characterized Ino80 complex and its binding partners to understand transcription elongation mechanism. We found that Ino80 regulates promoter-proximal pausing-like pattern of RNAPII and this activity is conserved in mouse embryonic stem cells, suggesting that Ino80 complex orchestrates a mechanism for proper transcription elongation, linking chromatin remodeling activity to productive mRNA synthesis mediated by RNAPII. In this talk, I will discuss the recent progress of our laboratory about chromatin remodeling complex that function within a defined window to promote Pol II processivity, elongation rate variation, and progression past polyadenylation sites in early gene body regions to prevent accumulation of immature, truncated transcripts.