제목	2021년 9월 16일 생물정보학 세미나
작성자	관리자	작성일	2021-09-14
서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다. 세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는 아래의 링크로 참여 부탁드리겠습니다. 일시: 2021년 9월 16일 목요일 오전 11시 연사: 하민진 연사님 (MD Anderson Cancer Center) Zoom link:　https://snu-ac-kr.zoom.us/j/83223741523 Title:　Integrative Network Modeling in Cancer Pharmacogenomics Abstract Integrative network modeling of data arising from multiple genomic platforms provides insight into the holistic picture of the interactive system, as well as the flow of information across many disease domains including cancer. The basic data structure consists of a sequence of hierarchically ordered datasets for each individual subject, which facilitates integration of diverse inputs, such as genomic, transcriptomic, and proteomic data. A primary analytical task in such contexts is to model the layered architecture of networks where the vertices can be naturally partitioned into ordered layers, dictated by multiple platforms, and exhibit both undirected and directed relationships. We propose a multilayered Gaussian graphical model (mlGGM) to investigate conditional independence structures in such multilevel genomic networks in human cancers. We implement a Bayesian node-wise selection (BANS) approach based on variable selection techniques that coherently accounts for the multiple types of dependencies in mlGGM; this flexible strategy exploits edge-specific prior knowledge and selects sparse and interpretable models. Through simulated data generated under various scenarios, we demonstrate that BANS outperforms other existing multivariate regression-based methodologies. Our integrative pharmacogenomic analysis of breast cancer cell lines for key signaling pathways highlights major mechanistic drivers for drug actions in Palbociclib and endocrine therapy including Tamoxifen and Fulvestrant.