Modern medicine has been successful with the emerging technology of molecular biology and genetics. However, despite continuous efforts, we are still facing the threat of chronic diseases, such as diabetes and neurodegenerative diseases, which projected to account for 73% of world-wide deaths at 2020. Unlike communicable diseases, the mechanism of chronic diseases remained vague yet, thus impeding the development of proper diagnostic and therapeutic.

In recent years, modern medicine is innovating based on a new paradigm shift, a data-driven medicine (Leroy Hood et al., Nat Rev Clin Oncol., 2011). Advancement of high-throughput molecular phenotyping, now all individual can generate their own personalized data clouds, and based on systems biology approaches, the complexity of human physiology of individuals can be understood.　　

In this seminar, the speaker will present recent systems biology approaches to understand health and disease, especially focusing on understanding human metabolism and microbiome of chronic diseases. Human microbiome is now well known that it substantially contributes to host metabolism and immune development, its dysbiosis contributing to the pathogenesis of many chronic diseases. Recently its importance has been highlighted due to the potential of increasing the efficacy of immunotherapy. In this seminar, the speaker will address the systems biology approaches and the future of systems medicine.