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ÀÛ¼ºÀÚ | °ü¸®ÀÚ | ÀÛ¼ºÀÏ | 2021-03-31 |
¼¿ï´ëÇб³ »ý¹°Á¤º¸ÇÐ Çùµ¿°úÁ¤ ÁÖÃÖ·Î ¼¼¹Ì³ª¸¦ ¾Æ·¡¿Í °°ÀÌ ¿°íÀÚ ÇÏ¿À´Ï ¸¹Àº Âü¿© ¹Ù¶ø´Ï´Ù. ¼¼¹Ì³ª´Â ZoomÀ» ÅëÇÑ ¿Â¶óÀÎ °ÀÇ·Î ¿¹Á¤µÇ¾î ÀÖÀ¸¸ç °ÀÇ¿¡ Âü¿©ÇÏ°íÀÚ ÇϽô ºÐ²²¼´Â ¾Æ·¡ÀÇ ¸µÅ©·Î Âü¿© ºÎŹµå¸®°Ú½À´Ï´Ù.¡¡ ÀϽÃ: 2021³â 4¿ù 8ÀÏ¡¡¸ñ¿äÀÏ ¿ÀÀü 11½Ã ¿¬»ç: ÇãÀͼö ¿¬»ç´Ô¡¡(¼¿ï´ëÇб³) Zoom link:¡¡https://snu-ac-kr.zoom.us/j/83338067211 Title:¡¡Two-stage clustering analysis to detect pattern change of biomarker expression between experimental conditions¡¡ Abstract In a crossover design, individuals usually undergo all experimental conditions, and the measurements of biomarkers are repeatedly observed at serial time points for each experimental condition. To analyse time-dependent changing patterns of biomarkers, clustering algorithms are commonly used across time points to group together subjects having similar changing patterns. Among the clustering methods, hierarchical- and K-means clustering have been popularly used. However, since they are originally unsupervised approaches, they do not identify different changing patterns between experimental conditions. Therefore, we propose a new two-stage clustering method focusing on changing patterns. The first stage is to eliminate non-informative biomarkers using Euclidean distances, and the second stage is to allocate the remaining biomarkers to predefined patterns using a correlation-based distance. We demonstrate the advantages of our proposed method by simulation and real data analysis.¡¡ |
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