제목	2020년 9월 16일 생물정보학 세미나
작성자	관리자	작성일	2020-09-11
서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다. 세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는　mari911@snu.ac.kr로 메일 주시면 강의 링크 전달드리도록 하겠습니다.　 일시:　　2020년 9월 16일　수요일 오전 11시 연사:　　이호선 연사님　(국립과학수사연구소) TITLE Epigenetic Clocks and Human Diseases Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. Many researchers have built age prediction models with high accuracy based on age-dependent methylation changes in certain CpG loci. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. For now, DNA methylation based on epigenetic clocks, namely epigenetic or DNA methylation age, serves as a new standard to track chronological age and predict biological age.　Currently, a growing number of studies have shown that dynamic DNA methylation throughout human lifetime exhibits strong correlation with age and age-related outcomes. In this lecture, we provide an overview of the dynamic signatures of DNA methylation during aging and emphasize its practical utility in the prediction of various age-related outcomes. In addition, we show four different epigenetic clocks (Pan-tissue, Hannum, PhenoAge, and GrimAge), and their accelerations, on metabolic syndrome and metabolic-related lifestyle factors, in Koreans.