서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니 많은 참여 바랍니다.

세미나는 Zoom을 통한 온라인 강의로 예정되어 있으며 강의에 참여하고자 하시는 분께서는　　mari911@snu.ac.kr로 메일 주시면 강의 링크 전달드리도록 하겠습니다.　

일시:　　2020년 4월 21일　화요일 오전 11시

연사:　　김권도 연사님　(서울대학교)

TITLE

Indigenous African cattle: unique genetic resources in a rapidly changing world

Abstract

Across African human societies, cattle play a crucial role as a source of animal proteins, draught power and wealth. The majority of African cattle are today indicine x taurine admixed populations with high genome diversities, a legacy of crossing between African taurine and multiple-introduced indicine. They are present across all agro-ecologies, from the driest to the most humid ones, with their successful adaptations to local environmental conditions. We present here several evidences that such success of African cattle pastoralism was driven by the indicine x taurine admixture. We analyzed whole genome sequences of 172 indigenous African cattle, representing 16 populations, and showed that the main taurine x indicine admixture events in African humped cattle date back to around 750 years ago. We then reconstructed the local ancestries of African humped cattle, and identified signature of positive selection. The selective sweeps with an excess of indicine as well as taurine ancestry include annotated genes underlying adaptive traits of unadmixed indicine or taurine cattle such as heat tolerance. We also identified a conserved haplotype commonly shared within African taurine, clearly distinct from Eurasian taurine and Asian indicine haplotypes. This unique haplotype is located upstream CARD11, a gene previously reported to be linked to trypanotolerance. Our findings suggest that a combination of different genetic resources shaped the genetic background of African cattle, and contributed the dispersion of cattle across diverse African agro-ecologies.