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TITLE

Cellular dynamics in cancer, at single cell resolution¡¡


ABSTRACT

¡¡Single cell transcriptome analysis is a powerful tool for defining cell types or cell states with thousands of gene expression data, within heterogeneous tissues or organs. We have applied the massively parallel single cell RNA sequencing to illustrate cellular landscape of diverse cancer tissues, in comparison to the simultaneously obtained matched normal tissues. In tumor tissues, the tissue-specific immune cell populations were replaced with those mediating tumor immunity. Cellular dynamics in various type of tumor tissues showing both common and distinct features in tumor microenvironment will be presented.